Hi Megan,
So, before doing the following steps below, it didn't matter if I took a complete or partial screenshot (CMD+Shift+3 or CMD+Shift+4) - DB still created multiple copies of the same shot.
I went on the DB download website and actually downloaded the "Offline installer (Apple Silicon)", ran the download .dmg file on my Mac and viola! I went into the app (v162.4.5419), re-checked the box to "Share screenshots and screen recordings using Dropbox" and now it seems to be working fine, no duplicate files being created. I will monitor my DB screenshots and let you all know if it happens again. Let me know if you'd like me to try anything else.
Thanks again for your time and responses.